Artificial intelligence-based multi-omics analysis fuels cancer precision medicine

X He, X Liu, F Zuo, H Shi, J Jing - Seminars in Cancer Biology, 2023 - Elsevier
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …

The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

A systematic review on the continuous cropping obstacles and control strategies in medicinal plants

M Zeeshan Ul Haq, J Yu, G Yao, H Yang… - International Journal of …, 2023 - mdpi.com
Continuous cropping (CC) is a common practice in agriculture, and usually causes serious
economic losses due to soil degeneration, decreased crop yield and quality, and increased …

Recent advances in metabolism and toxicity of tyrosine kinase inhibitors

Q Zhao, ZE Wu, B Li, F Li - Pharmacology & Therapeutics, 2022 - Elsevier
Small molecule tyrosine kinase inhibitors (TKIs) are widely used as anticancer drugs
approved by US FDA. However, the toxicities of TKIs to multiple organs have greatly limited …

Precise metabolomics reveals a diversity of aging‐associated metabolic features

H Tian, Z Ni, SM Lam, W Jiang, F Li, J Du… - Small …, 2022 - Wiley Online Library
Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …

A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect

L van Tetering, S Spies, QDK Wildeman… - Communications …, 2024 - nature.com
Modern untargeted mass spectrometry (MS) analyses quickly detect and resolve thousands
of molecular compounds. Although features are readily annotated with a molecular formula …

Mapping microhabitats of lignocellulose decomposition by a microbial consortium

M Veličković, R Wu, Y Gao, MW Thairu… - Nature Chemical …, 2024 - nature.com
The leaf-cutter ant fungal garden ecosystem is a naturally evolved model system for efficient
plant biomass degradation. Degradation processes mediated by the symbiotic fungus …

Integrating ion mobility into comprehensive multidimensional metabolomics workflows: critical considerations

JC May, JA McLean - Metabolomics, 2022 - Springer
Background Ion mobility (IM) separation capabilities are now widely available to researchers
through several commercial vendors and are now being adopted into many metabolomics …

[HTML][HTML] Metabolomics in drug research and development: The recent advances in technologies and applications

H Pang, Z Hu - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Emerging evidence has demonstrated the vital role of metabolism in various diseases or
disorders. Metabolomics provides a comprehensive understanding of metabolism in …

Current state and future perspectives on personalized metabolomics

OP Trifonova, DL Maslov, EE Balashova, PG Lokhov - Metabolites, 2023 - mdpi.com
Metabolomics is one of the most promising 'omics' sciences for the implementation in
medicine by developing new diagnostic tests and optimizing drug therapy. Since in …