Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Substance P (SP) is a highly conserved member of the tachykinin peptide family that is
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …

Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Characterised by chronic widespread musculoskeletal pain, generalised hyperalgesia, and
psychological distress, fibromyalgia (FM) is a significant unmet clinical need. The …

Research over the past few decades has established a role for the endocannabinoid system
in contributing to the neural and endocrine responses to stress exposure. The two …

Background: Accumulating evidence suggests that cannabidiol (CBD) may be an effective
and safe anxiolytic agent and potentially also an antidepressant. Aim: The objective of this …

The brain and peripheral nervous system provide oversight to muscle physiology and
metabolism. Muscle is the largest organ in the body and critical for glucose sensitivity …

Back-translating the clinical manifestations of human disease burden into animal models is
increasingly recognized as an important facet of preclinical drug discovery. We …

Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric
disorders, including anxiety and depression, represent significant clinical challenges …

Sustained exposure to stress or corticosteroids is known to cause changes in brain
endocannabinoid (eCB) signaling, such that tissue contents of the eCBs N …