We examined if resistance training affected muscle NAD+ and NADH concentrations as well
as nicotinamide phosphoribosyltransferase (NAMPT) protein levels and sirtuin (SIRT) …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …

Sirtuins are NAD+-dependent protein deacetylases that regulate metabolism and aging-
related processes. Sirt2 is the only cytoplasmic isoform among the seven mamalian Sirtuins …

4-Hydroxynonenal (4-HNE) is an endogenous product of lipid peroxidation known to play a
role in cellular signaling through protein modification and is a major precursor for protein …

Regenerative processes in brain pathologies require the production of distinct neural cell
populations from endogenous progenitor cells. We have previously demonstrated that …

Sirtuins are NAD+-dependent protein lysine deacylases implicated in aging-related
diseases. Mammalian Sirtuin 4 (Sirt4) is located in mitochondria and a potential therapeutic …

The protein acetylation of either the α-amino groups of amino-terminal residues or of internal
lysine or cysteine residues is one of the major posttranslational protein modifications that …

Sirtuins are NAD+-dependent deacetylases involved in chemical reversal of acetyllysine
modifications of cellular proteins. Deacetylation catalyzed by sirtuins is implicated in …

Sirtuins are NAD+ dependent deacylases enzymes. There are seven mammalian sirtuins,
SIRT1–SIRT7, which are localized to different cellular compartments and are capable of …

Most living organisms, including humans, age. Over time the ability to do physical and
intellectual work deteriorates, and susceptibility to infectious, metabolic, and …