The genetics of kidney stone disease and nephrocalcinosis

P Singh, PC Harris, DJ Sas, JC Lieske - Nature Reviews Nephrology, 2022 - nature.com
Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

CLC chloride channels and transporters: structure, function, physiology, and disease

TJ Jentsch, M Pusch - Physiological reviews, 2018 - journals.physiology.org
CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

[HTML][HTML] Magnesium in man: implications for health and disease

JHF De Baaij, JGJ Hoenderop… - Physiological …, 2015 - journals.physiology.org
Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

[HTML][HTML] Applications of supramolecular anion recognition

N Busschaert, C Caltagirone, W Van Rossom… - Chemical …, 2015 - ACS Publications
The study of the complexation of anions, from its beginnings in the late 1960s and 1970s,(1-
3) has moved on from being an area solely of academic interest to a fundamental pillar of …

Salt sensitivity of blood pressure: a scientific statement from the American Heart Association

F Elijovich, MH Weinberger, CAM Anderson… - …, 2016 - Am Heart Assoc
Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …

Exploring the genetic basis of early-onset chronic kidney disease

A Vivante, F Hildebrandt - Nature Reviews Nephrology, 2016 - nature.com
The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

[HTML][HTML] Genetics of human cardiovascular disease

S Kathiresan, D Srivastava - Cell, 2012 - cell.com
Cardiovascular disease encompasses a range of conditions extending from myocardial
infarction to congenital heart disease, most of which are heritable. Enormous effort has been …

Regulation of the renal NaCl cotransporter and its role in potassium homeostasis

EJ Hoorn, M Gritter, CA Cuevas… - Physiological …, 2020 - journals.physiology.org
Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

[HTML][HTML] Molecular mechanisms of human hypertension

RP Lifton, AG Gharavi, DS Geller - Cell, 2001 - cell.com
Hypertension, or elevated arterial blood pressure, is a been operationally defined as the
blood pressure level substantial public health problem, affecting 25% of the above which …

Molecular structure and physiological function of chloride channels

TJ Jentsch, V Stein, F Weinreich… - Physiological …, 2002 - journals.physiology.org
Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …