The non-coding RNA interactome in joint health and disease
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …
Mesenchymal stem cell-derived exosomes and microRNAs in cartilage regeneration: biogenesis, efficacy, miRNA enrichment and delivery
Exosomes are the small extracellular vesicles secreted by cells for intercellular
communication. Exosomes are rich in therapeutic cargos such as microRNA (miRNA), long …
communication. Exosomes are rich in therapeutic cargos such as microRNA (miRNA), long …
Biological roles and therapeutic potential of circular RNAs in osteoarthritis
X Mao, Y Cao, Z Guo, L Wang, C Xiang - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by
cartilage degeneration and narrow joint spaces. The regulatory functions of non-coding …
cartilage degeneration and narrow joint spaces. The regulatory functions of non-coding …
[HTML][HTML] Rhoifolin ameliorates osteoarthritis via the Nrf2/NF-κB axis: In vitro and in vivo experiments
H Chen, J Qin, H Shi, Q Li, S Zhou, L Chen - Osteoarthritis and cartilage, 2022 - Elsevier
Objective Osteoarthritis (OA) is an age-related degenerative disease accompanied by an
increasing number of senescent cells and chronic low-grade inflammation. Rhoifolin (ROF) …
increasing number of senescent cells and chronic low-grade inflammation. Rhoifolin (ROF) …
CircRNA-mediated ceRNA mechanism in osteoarthritis: special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation
Q Xue, Y Huang, J Chang, C Cheng, Y Wang… - Biochemical …, 2023 - Elsevier
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …
Expression and biological functions of miRNAs in chronic pain: A review on human studies
Chronic pain is a major public health problem and an economic burden worldwide.
However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are …
However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are …
Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction
J Elayyan, I Carmon, L Zecharyahu… - Proceedings of the …, 2022 - National Acad Sciences
Cartilage mineralization is a tightly controlled process, imperative for skeletal growth and
fracture repair. However, in osteoarthritis (OA), cartilage mineralization may impact the joint …
fracture repair. However, in osteoarthritis (OA), cartilage mineralization may impact the joint …
Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis
The aim of this review is to provide an updated review of the epigenetic factors involved in
the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint …
the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint …
[HTML][HTML] Implications and theragnostic potentials of circular RNAs in rheumatic diseases
AA Abbas, HA Abdulkader, R Giordo… - International Journal of …, 2023 - Elsevier
Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and
ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has …
ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has …
[HTML][HTML] Studies on the role of circRNAs in osteoarthritis
W Wu, J Zou - BioMed Research International, 2021 - hindawi.com
Objective. Provide a reference to elucidate the mechanism of circRNAs regulating
osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa …
osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa …