The non-coding RNA interactome in joint health and disease

SA Ali, MJ Peffers, MJ Ormseth, I Jurisica… - Nature Reviews …, 2021 - nature.com
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

Mesenchymal stem cell-derived exosomes and microRNAs in cartilage regeneration: biogenesis, efficacy, miRNA enrichment and delivery

JB Foo, QH Looi, CW How, SH Lee, ME Al-Masawa… - Pharmaceuticals, 2021 - mdpi.com
Exosomes are the small extracellular vesicles secreted by cells for intercellular
communication. Exosomes are rich in therapeutic cargos such as microRNA (miRNA), long …

Biological roles and therapeutic potential of circular RNAs in osteoarthritis

X Mao, Y Cao, Z Guo, L Wang, C Xiang - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by
cartilage degeneration and narrow joint spaces. The regulatory functions of non-coding …

[HTML][HTML] Rhoifolin ameliorates osteoarthritis via the Nrf2/NF-κB axis: In vitro and in vivo experiments

H Chen, J Qin, H Shi, Q Li, S Zhou, L Chen - Osteoarthritis and cartilage, 2022 - Elsevier
Objective Osteoarthritis (OA) is an age-related degenerative disease accompanied by an
increasing number of senescent cells and chronic low-grade inflammation. Rhoifolin (ROF) …

CircRNA-mediated ceRNA mechanism in osteoarthritis: special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Q Xue, Y Huang, J Chang, C Cheng, Y Wang… - Biochemical …, 2023 - Elsevier
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …

Expression and biological functions of miRNAs in chronic pain: A review on human studies

S Sabina, A Panico, P Mincarone, CG Leo… - International Journal of …, 2022 - mdpi.com
Chronic pain is a major public health problem and an economic burden worldwide.
However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are …

Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction

J Elayyan, I Carmon, L Zecharyahu… - Proceedings of the …, 2022 - National Acad Sciences
Cartilage mineralization is a tightly controlled process, imperative for skeletal growth and
fracture repair. However, in osteoarthritis (OA), cartilage mineralization may impact the joint …

Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis

HC Ball, AL Alejo, TK Samson, AM Alejo, FF Safadi - Life, 2022 - mdpi.com
The aim of this review is to provide an updated review of the epigenetic factors involved in
the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint …

[HTML][HTML] Implications and theragnostic potentials of circular RNAs in rheumatic diseases

AA Abbas, HA Abdulkader, R Giordo… - International Journal of …, 2023 - Elsevier
Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and
ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has …

[HTML][HTML] Studies on the role of circRNAs in osteoarthritis

W Wu, J Zou - BioMed Research International, 2021 - hindawi.com
Objective. Provide a reference to elucidate the mechanism of circRNAs regulating
osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa …