We previously optimized imipenem and tobramycin combination regimens against a double-
resistant clinical Pseudomonas aeruginosa isolate by using in vitro infection models …

Adaptive resistance following the first exposure to aminoglycosides is a recently described
in vitro phenomenon in Pseudomonas aeruginosa and other aerobic gram-negative bacilli …

Purpose Inappropriate use of broad-spectrum antibiotics contributes to the emergence of
multidrug-resistant (MDR) bacteria. Finding novel antimicrobial agents and strategies based …

The post-antibiotic effect (PAE) may allow for more widely spaced dosing of antibiotics than
is currently employed without loss of efficacy. Antimicrobial combinations are widely used in …

The effect of recombinant interferon-ã (rIFN-ã) on Cryptococcus neoformans infection was
investigated in vivo. BALB/c mice were injected intravenously with 2'd7 106 C. neoformans …

Background Alternative therapeutic regimens are urgently needed against carbapenemase-
producing Enterobacteriaceae. Fosfomycin often remains active against KPC and OXA-48 …

Antibiotic drug combination therapy is critical for the successful treatment of infections
caused by multidrug resistant pathogens. We investigated the efficacy of β-lactam and β …

Bacterial endocarditis is a deep, difficult-to-cure infection. Although most organisms are
highly susceptible to many antibiotics, therapy must be maintained for weeks in order to …

Nosocomial pneumonia, which is defined as a lower respiratory tract infection neither
present nor incubating on admission, is the second most frequent manifestation of hospital …

Investigators conducting clinical trials may have trouble rep-licating in ill patients results
obtained in tightly controlled models of efficacy and toxicity that use healthy animals [1] …