Optimal treatment strategies for serious infections caused by Staphylococcus aureus have
not been fully characterized. The combination of a β-lactam plus an aminoglycoside can act …

In vivo synergy with beta-lactam antibiotics and aminoglycosides has been studied only with
penicillin-susceptible Streptococcus pneumoniae strains. We evaluated the interaction …

To determine whether the infection-preventing capability of the neutrophil-activating agent
poly-(1-6)-β-d-glucopyranosyl-(1-3)-β-d-glucopyranose glucan (PGG-glucan) can be …

We report a case of pediatric pneumococcal endocarditis (PPE) and review the English
language literature on this disease. Thirty-two cases of PPE were identified since 1900. One …

In most developed countries, about 5-10% of all hospitalised patients develop a nosocomial
infection responsible for increased morbidity and mortality, prolonged stays in intensive care …

Aims: This study investigated the in vitro bactericidal activity of an intramammary drug
product by comparing the kill kinetics of cefalexin and kanamycin, alone and in fixed ratio …

The therapeutic activity of ceftobiprole medocaril, the prodrug of ceftobiprole, was compared
to that of vancomycin, daptomycin, and the combination of a subtherapeutic dose of …

Bacterial endocarditis is a difficult-to-curc infection, owing to (i) poor penetration of
antibiotics into infected vegetations;(ii) altered metabolic state of bacteria within the …

The objective of this study was to evaluate the in vitro and in vivo efficacies of linezolid (35
mg/kg/5 h), vancomycin (60 mg/kg/5 h), imipenem (30 mg/kg/5 h), linezolid+ imipenem …

Methicillin-resistant Staphylococcus aureus (MRSA) infections are commonly treated with
vancomycin (VAN) or another glycopeptide antibiotic. However, when vancomycin fails or …