Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

Meiosis is the unique division of germ cells resulting in the recombination of the maternal
and paternal genomes and the production of haploid gametes. In mammals, it begins during …

The combination of genome editing and primordial germ cell (PGC) transplantation has
enormous significance in the study of developmental biology and genetic breeding, despite …

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, are specified
during weeks 2− 3 after fertilization. Few studies on ex vivo and in vitro cultured human …

Reconstitution of germ cell fate from pluripotent stem cells provides an opportunity to
understand the molecular underpinnings of germ cell development. Here, we established …

Recently, 2 branches of the wide area of synthetic biology—in vitro gametogenesis and
synthetic embryo development—have gained considerable attention. Rodent induced …

Reconstitution of the germ cell lineage using pluripotent stem cells provides a unique
platform to deepen our understanding of the mechanisms underlying germ cell development …

Advanced molecular and cellular technologies provide promising tools for wildlife and
biodiversity conservation. Induced pluripotent stem cell (iPSC) technology offers an easily …

During fetal oocyte development in mammals, germ cells progress through meiotic prophase
I to form primordial follicles with pregranulosa cells. The primordial follicles remain dormant …