Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Cells organize many of their biochemical reactions in non-membrane compartments. Recent
evidence has shown that many of these compartments are liquids that form by phase …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Eukaryotic cells are complex structures capable of coordinating numerous biochemical
reactions in space and time. Key to such coordination is the subdivision of intracellular …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

The design and synthesis of 2D and 3D crystalline covalent organic frameworks (COFs) from
macromolecular and even infinite building units is largely undeveloped. Here, we report a …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

Precise regulation of centrosome number is critical for accurate chromosome segregation
and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers …