The global burden of psychopathologies appears to be underestimated, since the global
psychiatric disorder burden is exceeding other medical burdens. To be able to address this …

Stress is a normal response to situational pressures or demands. Exposure to stress
activates the hypothalamic-pituitary-adrenal (HPA) axis and leads to the release of …

Allergic rhinitis (AR) is a widespread disease that is frequently comorbid with depression.
However, the mechanisms and treatments for depression in AR remain underexplored …

Background Depression and diabetes mellitus (DM) are major chronic noncommunicable
diseases that impair one's mental and physical well-being and impose substantial burdens …

Electroconvulsive therapy (ECT) is one of the most effective strategies for treating resistant
major depression. Although the mechanism of action is not fully understood and studies are …

Background: Environmental factors make an important contribution to suicide. Histone tails
are prone to different modifications, leading to changes of chromatin (de) condensation and …

Background Hypotheses surrounding the etiology of depressive disorders encompass a
wide range of biological changes that can occur in a depressed individual, from gene …

Antidepressant response, the effectiveness of antidepressants in relieving symptoms of
depression, is a complex trait influenced by both genetic and environmental factors …

Background: Depression is one of the most common causes of disability in the world, and
one third of patients do not respond to currently available antidepressants, so a strategy is …

The advent of the 21st century has borne witness to the manifestation of concealed
pandemics, characterized by chronic illnesses of significant societal consequence, which …