A failure of hemostasis and consequent formation of blood clots in the circulatory system can
produce severe outcomes such as stroke and myocardial infraction. Pathological …

In patients with acute myocardial infarction, intravenous streptokinase therapy recanalizes
40% to 45% of occluded coronary arteries and reduces mortality by 25%. Recombinant …

The effects of bolus injections of recombinant single-chain tissue-type plasminogen activator
(rt-PA) and of F (ab') 2 fragments of a murine monoclonal antibody (7E3) against the human …

Thrombolytic therapy is an important treatment for thrombosis, a life-threatening condition in
cardiovascular diseases. However, the traditional thrombolytic therapies have often been …

Vampire bat saliva contains a plasminogen activator that presumably assists these
hematophagous animals during feeding. Here, we report that the vampire bat salivary …

Thrombosis is a life‐threatening pathological condition in which blood clots form in blood
vessels, obstructing or interfering with blood flow. Thrombolytic agents (TAs) are enzymes …

Thrombosis, the blockage of blood vessels with clots, can lead to acute myocardial infarction
and ischemic stroke, both leading causes of death. Other than surgical interventions to …

Smart poly (2-oxazoline)(POx)-based multifunctional polymer capsules that specifically
target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the …

Complementary DNAs coding for four Desmodus rotundus salivary plasminogen activators
(DSPAs) were isolated and characterized. The predicted amino acid sequences display …

Chemotherapy is a conventional cancer treatment in clinical settings. Although numerous
nano drug delivery systems have been developed, the chemotherapeutic effect is greatly …