[HTML][HTML] Regulation of neuronal communication by G protein-coupled receptors
Y Huang, A Thathiah - FEBS letters, 2015 - Elsevier
Neuronal communication plays an essential role in the propagation of information in the
brain and requires a precisely orchestrated connectivity between neurons. Synaptic …
brain and requires a precisely orchestrated connectivity between neurons. Synaptic …
[HTML][HTML] Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
CP Chang, KC Wu, CY Lin, Y Chern - Journal of Biomedical Science, 2021 - Springer
In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …
neurodegenerative diseases have progressively become greater socioeconomic burdens …
Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A 2A
receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over …
receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over …
[HTML][HTML] Understanding the role of adenosine A2AR heteroreceptor complexes in neurodegeneration and neuroinflammation
DO Borroto-Escuela, S Hinz, G Navarro… - Frontiers in …, 2018 - frontiersin.org
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or
extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal …
extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal …
[HTML][HTML] A2B Adenosine Receptors: When Outsiders May Become an Attractive Target to Treat Brain Ischemia or Demyelination
E Coppi, I Dettori, F Cherchi, I Bulli, M Venturini… - International Journal of …, 2020 - mdpi.com
Adenosine is a signaling molecule, which, by activating its receptors, acts as an important
player after cerebral ischemia. Here, we review data in the literature describing A2BR …
player after cerebral ischemia. Here, we review data in the literature describing A2BR …
[HTML][HTML] The selective antagonism of adenosine A2B receptors reduces the synaptic failure and neuronal death induced by oxygen and glucose deprivation in rat CA1 …
I Fusco, F Ugolini, D Lana, E Coppi, I Dettori… - Frontiers in …, 2018 - frontiersin.org
Ischemia is a multifactorial pathology characterized by different events evolving in time.
Immediately after the ischemic insult, primary brain damage is due to the massive increase …
Immediately after the ischemic insult, primary brain damage is due to the massive increase …
[HTML][HTML] Protective effect of adenosine A2B receptor agonist, BAY60-6583, against transient focal brain ischemia in rat
I Dettori, L Gaviano, F Ugolini, D Lana, I Bulli… - Frontiers in …, 2021 - frontiersin.org
Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to
excitotoxicity, followed by a secondary brain injury that develops hours to days after …
excitotoxicity, followed by a secondary brain injury that develops hours to days after …
[HTML][HTML] Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal …
E Augusto, FQ Gonçalves, JE Real, HB Silva… - Neurobiology of …, 2021 - Elsevier
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in
animal models of Alzheimer's disease through its extracellular catabolism by CD73 to …
animal models of Alzheimer's disease through its extracellular catabolism by CD73 to …
Adenosinergic pathway in Parkinson's disease: Recent advances and therapeutic perspective
Y Zhao, X Liu, G Yang - Molecular Neurobiology, 2023 - Springer
Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by α-
synuclein (α-syn) aggregation. In PD, the current mainstay of symptomatic treatment is …
synuclein (α-syn) aggregation. In PD, the current mainstay of symptomatic treatment is …
[HTML][HTML] Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder
JI Gomes, M Farinha-Ferreira, N Rei… - Pharmacological …, 2021 - Elsevier
Major depressive disorder (MDD) is the foremost cause of global disability, being
responsible for enormous personal, societal, and economical costs. Importantly, existing …
responsible for enormous personal, societal, and economical costs. Importantly, existing …