Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to
play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in …

Aims This study aimed to address inconsistencies in results between the H9C2 myocardial
hypoxia (MH) cell line and myocardial infarction (MI) rat models used in MI research. We …

In the heart, ageing is associated with DNA damage, oxidative stress, fibrosis and activation
of the activin signalling pathway, leading to cardiac dysfunction. The cardiac effects of activin …

Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B
(ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology …

Aging is a major risk factor for heart failure (HF) and is the leading cause of death worldwide.
Currently, the nature of the relationship between aging and HF is not entirely clear. Herein …

Background Activin A has been implicated in the pathogenesis of patients with chronic
hypertension and heart failure as well as patients with hypertensive disorders of pregnancy …

Numerous approaches are being developed to promote post-natal muscle growth based on
attenuating Myostatin/Activin signalling for clinical uses such as the treatment …

Daskalopoulou et al. challenge us to design future trials aimed at improving the diagnosis
and management of preeclampsia among pregnant women. Understanding the strong link …

Innate immunity is the body's first line of defense against infections. Innate immune cells
express pattern recognition receptors in distinct cellular compartments that are responsible …

Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome
characterized by signs and symptoms of HF in the presence of a normal left ventricular …