Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …

Metastatic melanoma accounts for approximately 80% of skin cancer-related deaths. Up to
now there has been no effective treatment for stage IV melanoma patients due to the …

Signals downstream of growth factor receptors play an important role in mammary
carcinogenesis. Recently, we demonstrated that the small GTPases ARF1 and ARF6 were …

Abstract Background The Src homology and collagen 4 (SHC4) is an important intracellular
adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma …

Genome-wide association studies using genotype data have had limited success in the
identification of variants associated with major depressive disorder (MDD). Haplotype data …

Proto-oncogenic Src homology and collagen (Shc) proteins have been considered
archetypal adaptors of epidermal growth factor receptor (EGFR)–mediated signaling. We …

Objective Chondrocyte hypertrophic differentiation, a key process in endochondral
ossification, is also a feature of osteoarthritis leading to cartilage destruction. Here we …

The Shc family of adaptor proteins are crucial mediators of a plethora of receptors such as
the tyrosine kinase receptors, cytokine receptors, and integrins that drive signaling pathways …

Background Understanding the mechanisms that regulate hair cell (HC) differentiation in the
organ of Corti (OC) is essential to designing genetic therapies for hearing loss due to HC …

Simple Summary Metastasis formation and dissemination is a complex process that relies
on several steps. Even though highly inefficient, metastasis spreading is the primary cause …