Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are
all strongly associated and are all reaching epidemic proportions. Whether there is a causal …

Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex
interplay of several pathways, including inflammation, immune activation, hypoxia, and …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), its
pathogenesis and clinical significance remain poorly defined. In this study, we examined …

In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic
elevations of glucose. The pathogenic effect of high glucose, possibly in concert with fatty …

Background Insulin resistance appears to be the best predictor of the development of
diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is …

Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …