Thiazolidinediones
H Yki-Järvinen - New England Journal of Medicine, 2004 - Mass Medical Soc
Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes,
very few agents have been introduced during the past 20 years. The thiazolidinediones …
very few agents have been introduced during the past 20 years. The thiazolidinediones …
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
LS Szczepaniak, P Nurenberg… - American Journal …, 2005 - journals.physiology.org
Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the criteria
used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance …
used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance …
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
G Boden, GI Shulman - European journal of clinical …, 2002 - Wiley Online Library
Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart,
liver and pancreas. However, chronically elevated plasma FFA appear to have …
liver and pancreas. However, chronically elevated plasma FFA appear to have …
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
JH Choi, AS Banks, TM Kamenecka, SA Busby… - Nature, 2011 - nature.com
PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs
including rosiglitazone and pioglitazone. These drugs are full classical agonists for this …
including rosiglitazone and pioglitazone. These drugs are full classical agonists for this …
Disordered lipid metabolism and the pathogenesis of insulin resistance
DB Savage, KF Petersen… - Physiological …, 2007 - journals.physiology.org
Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the …
accounts for many of its symptoms and complications, efforts to understand the …
Peroxisome proliferator‐activated receptor targets for the treatment of metabolic diseases
FA Monsalve, RD Pyarasani… - Mediators of …, 2013 - Wiley Online Library
Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is
growing in the adult and pediatric populations. The most widely recognized metabolic risk …
growing in the adult and pediatric populations. The most widely recognized metabolic risk …
The role of insulin resistance in nonalcoholic fatty liver disease
KM Utzschneider, SE Kahn - The Journal of Clinical …, 2006 - academic.oup.com
Context: Insulin resistance is an almost universal finding in nonalcoholic fatty liver disease
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …
Lipids and lipoproteins in patients with type 2 diabetes
RM Krauss - Diabetes care, 2004 - Am Diabetes Assoc
Insulin resistance and type 2 diabetes are associated with a clustering of interrelated plasma
lipid and lipoprotein abnormalities, which include reduced HDL cholesterol, a predominance …
lipid and lipoprotein abnormalities, which include reduced HDL cholesterol, a predominance …
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors
L Michalik, J Auwerx, JP Berger, VK Chatterjee… - Pharmacological …, 2006 - ASPET
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …
Diabetic dyslipidaemia: from basic research to clinical practice
MR Taskinen - Diabetologia, 2003 - Springer
The recognition that the increase of plasma triglyceride rich lipoproteins (TRLs) is
associated with multiple alterations of other lipoproteins species that are potentially …
associated with multiple alterations of other lipoproteins species that are potentially …