Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes,
very few agents have been introduced during the past 20 years. The thiazolidinediones …

Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the criteria
used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance …

Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart,
liver and pancreas. However, chronically elevated plasma FFA appear to have …

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs
including rosiglitazone and pioglitazone. These drugs are full classical agonists for this …

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the …

Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is
growing in the adult and pediatric populations. The most widely recognized metabolic risk …

Context: Insulin resistance is an almost universal finding in nonalcoholic fatty liver disease
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …

Insulin resistance and type 2 diabetes are associated with a clustering of interrelated plasma
lipid and lipoprotein abnormalities, which include reduced HDL cholesterol, a predominance …

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …

The recognition that the increase of plasma triglyceride rich lipoproteins (TRLs) is
associated with multiple alterations of other lipoproteins species that are potentially …