Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
KF Petersen, S Dufour, D Befroy, M Lehrke… - Diabetes, 2005 - Am Diabetes Assoc
To examine the mechanism by which moderate weight reduction improves basal and insulin-
stimulated rates of glucose metabolism in patients with type 2 diabetes, we used 1H …
stimulated rates of glucose metabolism in patients with type 2 diabetes, we used 1H …
Diacylglycerol-mediated insulin resistance
DM Erion, GI Shulman - Nature medicine, 2010 - nature.com
Understanding the molecular mechanisms of insulin resistance remains a major medical
challenge of the twenty-first century. Over the last half-century, many hypotheses have been …
challenge of the twenty-first century. Over the last half-century, many hypotheses have been …
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
KF Petersen, S Dufour, DB Savage… - Proceedings of the …, 2007 - National Acad Sciences
We examined the hypothesis that insulin resistance in skeletal muscle promotes the
development of atherogenic dyslipidemia, associated with the metabolic syndrome, by …
development of atherogenic dyslipidemia, associated with the metabolic syndrome, by …
Etiology of insulin resistance
KF Petersen, GI Shulman - The American journal of medicine, 2006 - Elsevier
Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the …
prevalence is set to increase dramatically over the coming decades. Understanding the …
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
K Morino, KF Petersen, S Dufour… - The Journal of …, 2005 - Am Soc Clin Investig
To further explore the nature of the mitochondrial dysfunction and insulin resistance that
occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents with …
occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents with …
Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
O Gavrilova, M Haluzik, K Matsusue, JJ Cutson… - Journal of Biological …, 2003 - ASBMB
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that mediates the
antidiabetic effects of thiazolidinediones. PPARγ is present in adipose tissue and becomes …
antidiabetic effects of thiazolidinediones. PPARγ is present in adipose tissue and becomes …
The molecular basis for oxidative stress-induced insulin resistance
JL Evans, BA Maddux, ID Goldfine - Antioxidants & redox signaling, 2005 - liebertpub.com
Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-
products of metabolism. However, accumulating evidence has revealed that reactive …
products of metabolism. However, accumulating evidence has revealed that reactive …
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a …
H Bays, L Mandarino… - The Journal of Clinical …, 2004 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle
and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte …
and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte …
Obesity as a cardiovascular risk factor
JR Sowers - The American journal of medicine, 2003 - Elsevier
The prevalence of overweight and obesity continues to increase rapidly in the United States,
with more than half of all adults currently overweight or obese. In general, people become …
with more than half of all adults currently overweight or obese. In general, people become …
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
KF Petersen, EA Oral, S Dufour… - The Journal of …, 2002 - Am Soc Clin Investig
Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and
visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered …
visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered …