To examine the mechanism by which moderate weight reduction improves basal and insulin-
stimulated rates of glucose metabolism in patients with type 2 diabetes, we used 1H …

Understanding the molecular mechanisms of insulin resistance remains a major medical
challenge of the twenty-first century. Over the last half-century, many hypotheses have been …

We examined the hypothesis that insulin resistance in skeletal muscle promotes the
development of atherogenic dyslipidemia, associated with the metabolic syndrome, by …

Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the …

To further explore the nature of the mitochondrial dysfunction and insulin resistance that
occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents with …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that mediates the
antidiabetic effects of thiazolidinediones. PPARγ is present in adipose tissue and becomes …

Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-
products of metabolism. However, accumulating evidence has revealed that reactive …

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle
and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte …

The prevalence of overweight and obesity continues to increase rapidly in the United States,
with more than half of all adults currently overweight or obese. In general, people become …

Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and
visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered …