Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that
regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as …

OBJECTIVE—The goals of this study were to determine whether improvements in metabolic
control can ameliorate the cognitive dysfunction associated with type 2 diabetes and …

OBJECTIVE—Pharmacological use of peroxisome proliferator–activated receptor (PPAR) δ
agonists and transgenic overexpression of PPARδ in mice suggest amelioration of features …

Peroxisome proliferator‐activated receptors (PPARs) are transcriptional factors involved in
the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in …

The effect of pioglitazone (PIO) on plasma adiponectin concentration, endogenous glucose
production (EGP), and hepatic fat content (HFC) was studied in 11 type 2 diabetic patients …

Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store
lipids, and was not historically recognized as an important organ in the regulation and …

Obesity and its co-morbidities, including type II diabetes, insulin resistance and
cardiovascular diseases, have become one of the biggest health issues of present times …

Background Insulin resistance is the best predictor for the development of type 2 diabetes.
Recent studies have shown that young, lean, insulin-resistant (IR) offspring of parents with …

Type 2 diabetes mellitus is characterised by insulin resistance as well as progressive
pancreatic β cell dysfunction. The cornerstone of current oral blood-glucose lowering …

Skeletal muscle insulin resistance has been implicated in the pathogenesis of nonalcoholic
fatty liver disease (NAFLD) and atherogenic dyslipidemia associated with the metabolic …