The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain
incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF …

The mechanisms that determine full recovery versus subsequent progressive CKD after AKI
are largely unknown. Because macrophages regulate inflammation as well as epithelial …

Renal fibrosis is a final stage of many forms of kidney disease and leads to impairment of
kidney function. The molecular pathogenesis of renal fibrosis is currently not well …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

Because fibrotic kidneys exhibit aberrant activation of β-catenin signaling, this pathway may
be a potential target for antifibrotic therapy. In this study, we examined the effects of β …

AKI confers increased risk of progression to CKD. αKlotho is a cytoprotective protein, the
expression of which is reduced in AKI, but the relationship of αKlotho expression level to AKI …

Abstract Background Mesenchymal stem cells (MSCs) have been reported to promote the
regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic …

Mesenchymal stem cells (MSCs) have emerged as ideal cell-based therapeutic candidates
for the structural and functional restoration of the diseased kidney. Glial cell line-derived …

The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …

Fibrotic disorders of the renal, pulmonary, cardiac, and hepatic systems are associated with
significant morbidity and mortality. Effective therapies to prevent or curtail the advancement …