HCC and molecular targeting therapies: Back to the future

L Rinaldi, E Vetrano, B Rinaldi, R Galiero, A Caturano… - Biomedicines, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of death from cancer in the
world. Recently, the effectiveness of new antiviral therapies and the HBV vaccine have …

Pharmacokinetic considerations for angiogenesis inhibitors used to treat hepatocellular carcinoma: an overview

R Borriello, L Cerrito, A Gasbarrini… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) is the fifth malignancy in terms of frequency
and the fourth malignancy in terms of cancer-related death worldwide. Systemic therapy of …

A novel microcrystalline BAY-876 formulation achieves long-acting antitumor activity against aerobic glycolysis and proliferation of hepatocellular carcinoma

H Yang, MZ Zhang, H Sun, Y Chai, X Li, Q Jiang… - Frontiers in …, 2021 - frontiersin.org
BAY-876 is an effective antagonist of the Glucose transporter type 1 (GLUT1) receptor, a
mediator of aerobic glycolysis, a biological process considered a hallmark of hepatocellular …

Knockdown of FBI-1 Inhibits the Warburg Effect and Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents via miR-3692/HIF-1α

J Liu, C Yang, XM Huang, PP Lv, YK Yang… - Frontiers in …, 2021 - frontiersin.org
The transcription suppressor factor FBI-1 (the factor that binds to inducer of short transcripts-
1) is an important regulator of hepatocellular carcinoma (HCC). In this work, the results …

Sempervirine inhibits proliferation and promotes apoptosis by regulating wnt/β-catenin pathway in human hepatocellular carcinoma

R Yue, H Liu, Y Huang, J Wang, D Shi, Y Su… - Frontiers in …, 2021 - frontiersin.org
Gelsemium elegans (G. elegans) Benth., recognized as a toxic plant, has been used as
traditional Chinese medicine for the treatment of neuropathic pain and cancer for many …

Novel nanocrystal injection of insoluble drug anlotinib and its antitumor effects on hepatocellular carcinoma

M Luo, H Sun, Q Jiang, Y Chai, C Li, B Yang… - Frontiers in …, 2021 - frontiersin.org
The molecularly targeted agent anlotinib offers a novel therapeutic strategy against
advanced hepatocellular carcinoma (HCC). With this study, we aimed to solve the technical …

[HTML][HTML] Small molecule inhibitors for cancer metabolism: promising prospects to be explored

D Liu, HP Wang, XX Li, JF Liu, YL Zhang… - Journal of Cancer …, 2023 - Springer
Background Abnormal metabolism is the main hallmark of cancer, and cancer metabolism
plays an important role in tumorigenesis, metastasis, and drug resistance. Therefore …

The Combination of AFP and “Up-To-Seven” Criteria May Be a Better Strategy for Liver Transplantation in Chinese Cirrhotic HCC Patients

D Zhang, D Feng, X He, X Zhang, L Li, Z Li… - Frontiers in …, 2022 - frontiersin.org
Background Orthotopic liver transplantation (OLT) is a life-saving option for patients with
hepatocellular carcinoma (HCC), but the expanded OLT criteria remain controversial …

Glucose transporters: Important regulators of endometrial cancer therapy sensitivity

X Zhang, JJ Lu, A Abudukeyoumu, DY Hou… - Frontiers in …, 2022 - frontiersin.org
Glucose is of great importance in cancer cellular metabolism. Working together with several
glucose transporters (GLUTs), it provides enough energy for biological growth. The main …

[PDF][PDF] HCC and Molecular Targeting Therapies: Back to the Future. Biomedicines 2021, 9, 1345

L Rinaldi, E Vetrano, B Rinaldi, R Galiero, A Caturano… - 2021 - researchgate.net
Hepatocellular carcinoma (HCC) is one of the leading causes of death from cancer in the
world. Recently, the effectiveness of new antiviral therapies and the HBV vaccine have …