The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

People with Down syndrome show signs of chronic immune dysregulation, including a
higher prevalence of autoimmune disorders, increased rates of hospitalization during …

Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …

Metabolic reprogramming powers and polarizes macrophage functions, but the nature and
regulation of this response during infection with pathogens remain controversial. In this …

Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major
cause of tuberculosis (TB). Once phagocytized, Mtb resists killing by macrophages …

The continued threat of emerging, highly lethal infectious pathogens such as Middle East
respiratory syndrome coronavirus (MERS‐CoV) calls for the development of novel vaccine …