Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

Abstract Background Both Chili pepper (CP) and Sichuan pepper (SP) have long been used
for culinary purposes throughout Asia. It is well known CP and SP are well accompanied in …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …

Emodin is a natural occurring anthraquinone derivative isolated from roots and barks of
numerous plants, molds, and lichens. It is found to be an active ingredient in different …

Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1)
channel and is a common component found in the fruits of the genus Capsicum plants …

Capsaicin and dihydrocapsaicin (DHC) are major pungent capsaicinoids produced in chili
peppers. Capsaicin has been previously shown to promote vascular health by increasing …

Impaired cognition is the primary symptom of dementia, which can lead to functional
disability and reduced quality of life among an increasingly ageing population. Ageing is …

Purpose Dysfunction of endothelial cells plays a key role in the pathogenesis of diabetic
atherosclerosis. High glucose (HG) has been found as a key factor in the progression of …

TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …