Functional neurological disorder (FND), previously regarded as a diagnosis of exclusion, is
now a rule-in diagnosis with available treatments. This represents a major step toward …

This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …

Functional neurological disorder reflects impairments in brain networks leading to
distressing motor, sensory and/or cognitive symptoms that demonstrate positive clinical …

This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …

Interoception has historically been assessed using behavioural tests of accuracy, self-report
measures or through the characterisation of neural signals underlying interoceptive …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Importance Functional neurological disorders (FND) are common sources of disability in
medicine. Patients have often been misdiagnosed, correctly diagnosed after lengthy delays …

We review a recent shift in conceptions of interoception and its relationship to hierarchical
inference in the brain. The notion of interoceptive inference means that bodily states are …

How is it that thoroughly physical material beings such as ourselves can think, dream, feel,
create and understand ideas, theories and concepts? How does mere matter give rise to all …

To survive, organisms must effectively respond to the challenge of maintaining their
physiological integrity in the face of an ever-changing environment. Preserving this …