The pericyte microenvironment during vascular development

LB Payne, H Zhao, CC James, J Darden… - …, 2019 - Wiley Online Library
Vascular pericytes provide critical contributions to the formation and integrity of the blood
vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis …

Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy

SF Nabavi, AJ Barber, C Spagnuolo… - Critical Reviews in …, 2016 - Taylor & Francis
Diabetic retinopathy is a microvascular complication of diabetes that is considered one of
the leading causes of blindness among adults. More than 4.4 million people suffer from this …

[HTML][HTML] Updates on gene therapy for diabetic retinopathy

JH Wang, GE Roberts, GS Liu - Current Diabetes Reports, 2020 - Springer
Abstract Purpose of Review Diabetic retinopathy (DR), a leading cause of visual impairment
in the developed country, is characterized by vascular lesions and neuronal damage of the …

Retinal sensitivity loss correlates with deep capillary plexus impairment in diabetic macular ischemia

F Scarinci, M Varano, M Parravano - Journal of Ophthalmology, 2019 - Wiley Online Library
Purpose. To assess retinal sensitivity and retinal morphologic changes of capillary
nonperfused areas in diabetic macular ischemia. Methods. Observational cross‐sectional …

[HTML][HTML] Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve: galectin-3 participation

HR Mendonça, R Carpi-Santos… - Neural regeneration …, 2020 - journals.lww.com
Diabetes is a lifelong disease characterized by glucose metabolic imbalance, in which low
insulin levels or impaired insulin signaling lead to hyperglycemic state. Within 20 years of …

Arginase in retinopathy

SP Narayanan, M Rojas, J Suwanpradid… - Progress in retinal and …, 2013 - Elsevier
Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and
retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each …

[HTML][HTML] Ophthalmic intervention of naringenin decreases vascular endothelial growth factor by counteracting oxidative stress and cellular damage in in vivo zebrafish

G Sudhakaran, A Chandran, AR Sreekutty, S Madesh… - Molecules, 2023 - mdpi.com
Diabetes Mellitus is a metabolic disease that leads to microvascular complications like
Diabetic retinopathy (DR), a major cause of blindness worldwide. Current medications for …

Retinal degeneration induced in a mouse model of ischemia–reperfusion injury and its management by pemafibrate treatment

D Lee, A Nakai, Y Miwa, Y Tomita, H Kunimi… - The FASEB …, 2022 - Wiley Online Library
Retinal ischemia–reperfusion (I/R) injury is a common cause of visual impairment. To date,
no effective treatment is available for retinal I/R injury. In addition, the precise pathological …

[HTML][HTML] Loss of Synaptic Connectivity, Particularly in Second Order Neurons Is a Key Feature of Diabetic Retinal Neuropathy in the Ins2Akita Mouse

JR Hombrebueno, M Chen, RG Penalva, H Xu - PloS one, 2014 - journals.plos.org
Retinal neurodegeneration is a key component of diabetic retinopathy (DR), although the
detailed neuronal damage remains ill-defined. Recent evidence suggests that in addition to …

Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy

L Sauer, KM Andersen, C Dysli… - … of biomedical optics, 2018 - spiedigitallibrary.org
Autofluorescence-based imaging techniques have become very important in the
ophthalmological field. Being noninvasive and very sensitive, they are broadly used in …