Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …

Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used …

Neuropsychiatric disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ)
and bipolar disorder (BPD) are of great societal and medical importance, but the complexity …

Several studies support currently the hypothesis that autism etiology is based on a polygenic
and epistatic model. However, despite advances in epidemiological, molecular and clinical …

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

Abstract 'Hyperfocus' is a phenomenon that reflects one's complete absorption in a task, to a
point where a person appears to completely ignore or 'tune out'everything else. Hyperfocus …

Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

In the context of current concerns about replication in psychological science, we describe 10
findings from behavioral genetic research that have replicated robustly. These are “big” …