Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms

PMP Ferreira, RWR de Sousa… - Pharmacological …, 2021 - Elsevier
Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to
relieve acute and chronic inflammatory diseases. In this article, we present a review about …

Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights

H Zalpoor, M Bakhtiyari, A Akbari, F Aziziyan… - Cell Communication and …, 2022 - Springer
Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival
characterized by abnormal cell proliferation and differentiation. Despite advances in …

New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone

LS Santos, VR Silva, MVL de Castro, RB Dias… - Cell Death & …, 2023 - nature.com
In this work, we describe a novel ruthenium-xanthoxylin complex,[Ru (phen) 2
(xant)](PF6)(RXC), that can eliminate colorectal cancer (CRC) stem cells by targeting the …

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Z Deng, D Shen, M Yu, F Zhou, D Shan, Y Fang… - Cell death …, 2023 - nature.com
Pectolinarigenin (PEC), an active compound isolated from traditional herbal medicine, has
shown potential anti-tumor properties against various types of cancer cells. However, its …

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Y Zhou, L Tao, J Qiu, J Xu, X Yang, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

How the innate immune DNA sensing cGAS–STING pathway is involved in autophagy

W Zheng, N Xia, J Zhang, N Chen, F Meurens… - International Journal of …, 2021 - mdpi.com
The cGAS–STING pathway is a key component of the innate immune system and exerts
crucial roles in the detection of cytosolic DNA and invading pathogens. Accumulating …

[HTML][HTML] Wnt/β-catenin targeting in liver carcinoma through nanotechnology-based drug repurposing: a review

P Mohapatra, N Chandrasekaran - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Liver cancer is the fifth most widespread in the world, with a high fatality rate and poor
prognosis. However, surgicalresction, thermal/radiofrequencyablation, chemo …

An overview of hepatocellular carcinoma after insufficient radiofrequency ablation

Y Guo, Y Ren, X Dong, X Kan… - Journal of Hepatocellular …, 2022 - Taylor & Francis
Radiofrequency ablation (RFA) is a commonly used treatment for hepatocellular carcinoma
(HCC), however, various complex conditions in clinical practice may lead to insufficient …

Novel selenoesters as a potential tool in triple-negative breast cancer treatment

D Radomska, R Czarnomysy, A Szymanowska… - Cancers, 2022 - mdpi.com
Simple Summary Breast cancer ranks at the forefront of all malignancies worldwide, and the
numerous incidences and mortality rate associated with it are very burdensome to the health …

A novel ruthenium complex with 5-fluorouracil suppresses colorectal cancer stem cells by inhibiting Akt/mTOR signaling

VR Silva, LS Santos, MVL de Castro, RB Dias… - Cell Death …, 2023 - nature.com
Abstract [Ru (5-FU)(PPh3) 2 (bipy)] PF6 (Ru/5-FU) is a novel ruthenium complex with 5-
fluorouracil with promising potential against colorectal cancer (CRC). In the present study …