Introduction: Immunization has been a remarkably successful public health intervention;
however, new approaches to vaccine design are essential to counter existing and emerging …

Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its
native form. The B cell receptor used in recognition can also be secreted to bind to antigens …

Lymph nodes (LNs) capture microorganisms that breach the body's external barriers and
enter draining lymphatics, limiting the systemic spread of pathogens. Recent work has …

Objective Clinical studies indicate that anti‐CD20 B‐cell depletion may be an effective
multiple sclerosis (MS) therapy. We investigated mechanisms of anti‐CD20‐mediated …

Germinal centers (GC) are sites of rapid B‐cell proliferation in response to certain types of
immunization. They arise in about 1 week and can persist for several months. In GC s, B …

Germinal centers (GCs) are specialized microenvironments formed after infection where
activated B cells can mutate their B‐cell receptors to undergo affinity maturation. A stringent …

Here we describe the spatiotemporal architecture, at high molecular resolution, of receptors
and signaling molecules during the early events of mouse B cell activation. In response to …

The splenic marginal zone is a unique microenvironment where resident immune cells are
exposed to the open blood circulation,. Even though it has an important role in responses …

B helper follicular T (Tfh) cells are critical for long-term humoral immunity. However, it
remains unclear how these cells are recruited and contribute to secondary immune …

Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …