In the lymphatic sinuses of draining lymph nodes, soluble lymph-borne antigens enter the
reticular conduits in a size-selective manner and lymphocytes transmigrate to the …

Inflammation is a highly dynamic process with immune cells that continuously interact with
each other and parenchymal components as they migrate through tissue. The dynamic …

The dermis and epidermis are alternative sites for prophylactic vaccination that have
received renewed interest in recent years, not only because of the ease of access to the …

Multivalent viral epitopes induce rapid, robust and T cell-independent humoral immune
responses, but the biochemical basis for such potency remains incompletely understood …

Secondary lymphoid organs (SLOs) are tissues that facilitate the induction of adaptive
immune responses. These organs capture pathogens to limit their spread throughout the …

CD169+ macrophages have fascinated immunologists because of their unique distribution
in secondary lymphoid organs, redistribution upon immune activation and, lately, because of …

Germinal centers (GCs) that form within lymphoid follicles during antibody responses are
sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic …

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble
protein vaccines, but the immune mechanisms underpinning this effect remain poorly …

Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived
from Gram-negative bacteria engineered to provide an over-vesiculating phenotype, which …

Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals
and by pathways characteristic of the activation of innate immunity cells that also operate in …