B cells are activated in vivo after the B cell receptors (BCRs) bind to antigens captured on
the surfaces of antigen-presenting cells. Antigen binding results in BCR microclustering and …

Acute viral infections are characterized by rapid increases in viral load, leading to cellular
damage and the resulting induction of complex innate and adaptive antiviral immune …

B cells play a critical role in immune responses by producing antibodies against the foreign
pathogens that they encounter. Their responses are initiated when the B cell receptor (BCR) …

Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts
to uninfected cells, a process called trans-infection. Whether trans-infection contributes to …

B cells are selected by the binding of antigen to clonally distributed B cell receptors (BCRs),
triggering signalling cascades that result in B cell activation. With the recent application of …

The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Immunoglobulin G (IgG)-mediated activation of complement and IgG Fc receptors (FcγRs)
are important defense mechanisms of the innate immune system to ward off infections …

The first step in inducing pulmonary adaptive immunity to allergens and airborne pathogens
is Ag acquisition and transport to the lung draining lymph nodes (dLN). Dendritic cells (DC) …

In lymph nodes, subcapsular sinus macrophages (SSMs) form an immunological barrier that
monitors lymph drained from peripheral tissues. Upon infection, SSMs activate B and natural …

Lymph node (LN) targeting through interstitial drainage of nanoparticles (NPs) is an
attractive strategy to stimulate a potent immune response, as LNs are the primary site for …