Blood group antigens represent polymorphic traits inherited among individuals and
populations. At present, there are 34 recognized human blood groups and hundreds of …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Although information about the precise world distribution and frequency of the inherited
hemoglobin disorders is still limited, there is no doubt that they are going to pose an …

Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Malaria is a major killer of children worldwide and the strongest known force for evolutionary
selection in the recent history of the human genome. The past decade has seen growing …

Malaria is a serious parasitic disease in the developing world, causing high morbidity and
mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease …

The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

Severe malaria has a high mortality rate (15–20%) despite treatment with effective
antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease …

Long considered a benign infection, Plasmodium vivax is now recognized as a cause of
severe and fatal malaria, despite its low parasite biomass, the increased deformability of …

Many human genetic associations with resistance to malaria have been reported, but few
have been reliably replicated. We collected data on 11,890 cases of severe malaria due to …