Background The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary
disease (COPD) has been the subject of much controversy. Major international guidelines …

Corticosteroids are widely used as effective treatments for the control of chronic
inflammatory diseases. However, because their long-term administration carries serious …

Introduction: A common extrapulmonary effect to chronic obstructive pulmonary disease
(COPD) is osteoporosis. Objectives: To characterise the diagnostic activity regarding …

Chronic obstructive pulmonary disease (COPD) is associated with numerous comorbidities,
among which osteoporosis is of high significance. Low bone mass and the occurrence of …

Chronic obstructive pulmonary disease (COPD) has been described as a heterogeneous
multifactorial disorder associated with an abnormal inflammatory response of the peripheral …

Background The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary
disease (COPD) has been the subject of much uncertainty. COPD clinical guidelines …

Aims: The purpose of this article is to review the clinical potential of roflumilast, a PDE4
inhibitor currently in phase III clinical trials, in the management of patients with COPD …

This dissertation is about the development of gene expression signature (GES) search
methods and their application in drug discovery, specifically for promoting healthy aging …

This chapter is concerned with the external pulmonary respiration dealing with the input of
atmospheric air (rich in O2) and output of bodily air (rich in CO2)(Fig. 1), as well as the …

Introduction: Dementia may be caused by Alzheimer's disease (AD), cerebrovascular
disease (CVD), or a combination of both. When CVD is associated with dementia, survival is …