The participation of platelets in atherogenesis and the subsequent formation of occlusive
thrombi depend on platelets' adhesive properties and the inability to respond to stimuli with …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains
linked together by 29 disulfide bonds. It is 45 nm in length, with globular domains at each …

Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Fibulins are a newly recognized family of extracellular matrix proteins. The five known
members of the family share an elongated structure and many calcium-binding sites, owing …

The valves of the heart develop in the embryo from precursor structures called endocardial
cushions. After cardiac looping, endocardial cushion swellings form and become populated …

Platelet-adhesive mechanisms play a well-defined role in hemostasis and thrombosis, but
evidence continues to emerge for a relevant contribution to other pathophysiological …

Background Thrombosis is the pathological basis of cardiovascular and cerebrovascular
diseases, which seriously threaten human life and health. Among them, nearly half of …

Venom gland transcriptomes and proteomes of six Micrurus taxa (M. corallinus, M.
lemniscatus carvalhoi, M. lemniscatus lemniscatus, M. paraensis, M. spixii spixii, and M …

Background In order to better understand the effects of social stress on the prefrontal cortex,
we investigated gene expression in mice subjected to acute and repeated social encounters …