Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases
Z Szekanecz, IB McInnes, G Schett… - Nature Reviews …, 2021 - nature.com
Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …
[HTML][HTML] The role of epigenetics in autoimmune/inflammatory disease
AEA Surace, CM Hedrich - Frontiers in immunology, 2019 - frontiersin.org
Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …
and caused by the innate immune system or autoimmune and driven by adaptive immune …
[HTML][HTML] The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts
The tumor microenvironment (TME) is comprised of non-malignant cells that interact with
each other and with cancer cells, critically impacting cancer biology. The TME is complex …
each other and with cancer cells, critically impacting cancer biology. The TME is complex …
Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in …
S Yang, F Li, S Lu, L Ren, S Bian, M Liu, D Zhao… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Panax ginseng CA Meyer is a type of herbal plant that has
frequently been used in many Asian countries to treat a variety of diseases. Ginseng is …
frequently been used in many Asian countries to treat a variety of diseases. Ginseng is …
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264. 7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt …
S Li, Q Dai, S Zhang, Y Liu, Q Yu, F Tan, S Lu… - Acta Pharmacologica …, 2018 - nature.com
Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from
human urine with strong anti-inflammatory and cytoprotective actions, which is widely used …
human urine with strong anti-inflammatory and cytoprotective actions, which is widely used …
Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups
JS Massias, EMD Smith, E Al-Abadi, K Armon… - Lupus, 2020 - journals.sagepub.com
Background Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory
condition. Approximately 15–20% of patients develop symptoms before their 18th birthday …
condition. Approximately 15–20% of patients develop symptoms before their 18th birthday …
[HTML][HTML] The molecular pathophysiology of psoriatic arthritis—the complex interplay between genetic predisposition, epigenetics factors, and the microbiome
AL Carvalho, CM Hedrich - Frontiers in molecular biosciences, 2021 - frontiersin.org
Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In
a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the …
a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the …
Autoinflammatory and autoimmune contributions to complex regional pain syndrome
J David Clark, VL Tawfik, M Tajerian… - Molecular …, 2018 - journals.sagepub.com
Complex regional pain syndrome (CRPS) is a highly enigmatic syndrome typically
developing after injury or surgery to a limb. Severe pain and disability are common among …
developing after injury or surgery to a limb. Severe pain and disability are common among …
The NLRP3 inflammasome-interleukin 1 pathway as a therapeutic target in gout
Z Szekanecz, S Szamosi, GE Kovács, E Kocsis… - Archives of biochemistry …, 2019 - Elsevier
The NLRP3 inflammasome is implicated in the processing of the pro-inflammatory cytokine
interleukin 1β. Inflammatory disorders associated with the activation of the NLRP3 …
interleukin 1β. Inflammatory disorders associated with the activation of the NLRP3 …
Juvenile-onset systemic lupus erythematosus (jSLE)–Pathophysiological concepts and treatment options
CM Hedrich, EMD Smith, MW Beresford - Best practice & research Clinical …, 2017 - Elsevier
The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE)
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …