The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Abstract The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …

The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

The transforming growth factor β (TGF-β) signaling pathway plays a key role in different
physiological processes such as development, cellular proliferation, extracellular matrix …

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis.
Evasion of apoptosis can be part of a cellular stress response to ensure the cell′ s survival …