Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis

JE Kim, E Roh, MH Lee, DH Yu, DJ Kim, TG Lim… - Oncogene, 2016 - nature.com
Solar ultraviolet (UV) light is a major etiological factor in skin carcinogenesis, with solar UV-
stimulated signal transduction inducing pathological changes and skin damage. The primary …

Targeting mitogen-activated protein kinases by natural products: a novel therapeutic approach for inflammatory bowel diseases

M Zobeiri, S Momtaz, F Parvizi, D Tewari… - Current …, 2020 - ingentaconnect.com
An increase in the prevalence of Inflammatory Bowel Diseases (IBD) as a multifactorial
intestinal chronic inflammation as well as the absence of a certain cure, has created an …

Ligand, receptor, and cell type–dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells

SE Trasino, YS Kim, TTY Wang - Molecular cancer therapeutics, 2009 - AACR
Recent evidence suggests that the liver X receptor (LXR) is a potential anticancer target in
prostate carcinoma. There is little characterization, however, of which of the two LXR …

[HTML][HTML] p38γ overexpression in gliomas and its role in proliferation and apoptosis

K Yang, Y Liu, Z Liu, J Liu, X Liu, X Chen, C Li… - Scientific reports, 2013 - nature.com
The objective of this study was to confirm the biological role of p38γ in human gliomas. The
expression profiles of p38γ and hTERT in human glioma samples were detected by Western …

[HTML][HTML] Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling

X Yang, J Wang, J Dai, J Shao, J Ma, C Chen, S Ma… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Liver dysfunction is a common side effect associated with the treatment of dasatinib and its
mechanism is poorly understood. Autophagy has been thought to be a potent survival or …

[HTML][HTML] The p38 MAPK regulates IL-24 expression by stabilization of the 3′ UTR of IL-24 mRNA

K Otkjaer, H Holtmann, TW Kragstrup, SR Paludan… - PloS one, 2010 - journals.plos.org
Background IL-24 (melanoma differentiation-associated gene-7 (mda-7)), a member of the
IL-10 cytokine family, possesses the properties of a classical cytokine as well as tumor …

Evidence of p38γ and p38δ involvement in cell transformation processes

MI Cerezo-Guisado, P Reino, G Remy, Y Kuma… - …, 2011 - academic.oup.com
The p38 mitogen-activated protein kinase (p38MAPK) signal transduction pathway is an
important regulator of cell processes, whose deregulation leads to the development and …

[HTML][HTML] p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to …

X Qi, H Zhi, A Lepp, P Wang, J Huang, Z Basir… - Journal of Biological …, 2012 - ASBMB
Estrogen receptor (ER) α promotes breast cancer growth by regulating gene expression
through classical estrogen response element (ERE) binding and nonclassical (interaction …

Increased oxidative stress response in granulocytes from older patients with a hip fracture may account for slow regeneration

Z Wang, S Ehnert, C Ihle, L Schyschka… - Oxidative medicine …, 2014 - Wiley Online Library
Proximal femur fracture, a typical fracture of the elderly, is often associated with morbidity,
reduced quality of life, impaired physical function and increased mortality. There exists …

Migration induced by epidermal and hepatocyte growth factors in oral squamous carcinoma cells in vitro: role of MEK/ERK, p38 and PI‐3 kinase/Akt

IJ Brusevold, M Aasrum, M Bryne… - Journal of oral …, 2012 - Wiley Online Library
J Oral Pathol Med (2012) 41: 547–558 Background: Cell migration is a necessary part of
malignant invasiveness. Oral squamous cell carcinomas (OSCC) have a great tendency for …