Bioactive components of dietary phytochemicals have been reported to possess antitumor
activities. Evidences suggested key role of stress responsive p38MAPK in the induction of …

Multiple studies are currently targeting dysregulated cancer cell metabolism with distinct
combinations of inhibitors. In this study, we evaluated in pancreatic cancer cells metformin …

The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array
of tissues where it is likely to have specific functions. This review aims to highlight recent …

Despite the high frequency of KRAS mutations in non‑small cell lung cancer (NSCLC),
therapeutic modalities targeting KRAS‑mutated NSCLC have not been established. Based …

p38 Mitogen-activated protein kinase (p38 MAPK) is a protein kinase critically involved in
the progress of inflammation/stress-associated diseases. Our data suggested that javamide …

In breast cancer, overexpression of Estrogen Receptor α-66 (ER-α66) is common and is
observed in nearly 70% of tissues (cancerous breast cancer). This receptor and its …

Ras signals through both mitogenic and stress pathways and studies of Ras regulatory
effects of stress pathways hold great promise to control Ras-dependent malignancies. Our …

In carcinogenesis, determination of gene and protein expression profiles is important for
prevention and treatment. Caffeic acid phenethyl ester (CAPE) in a single dose administered …

Cancer, along with cardiovascular disorders, is one of the most important problems of
healthcare. Pathologies of the hematopoietic system are the most prevalent in patients …

Ligands, agonists, or antagonists use receptor-mediated endocytosis (RME) to reach their
intracellular targets. After the internalization of ligand-receptor complexes, it traffics through …