Autophagy as a molecular target for cancer treatment
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells
Y Zhang, W Yu, M Chen, B Zhang, L Zhang, P Li - Nanoscale, 2023 - pubs.rsc.org
Nanozymes are nanomaterials with catalytic properties similar to those of natural enzymes,
and they have recently been collectively identified as a class of innovative artificial enzymes …
and they have recently been collectively identified as a class of innovative artificial enzymes …
[HTML][HTML] A genome-wide positioning systems network algorithm for in silico drug repurposing
Recent advances in DNA/RNA sequencing have made it possible to identify new targets
rapidly and to repurpose approved drugs for treating heterogeneous diseases by the …
rapidly and to repurpose approved drugs for treating heterogeneous diseases by the …
[HTML][HTML] Everything old is new again: drug repurposing approach for non-small cell lung cancer targeting MAPK signaling pathway
Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
[HTML][HTML] Is there a role of autophagy in depression and antidepressant action?
NC Gassen, T Rein - Frontiers in Psychiatry, 2019 - frontiersin.org
Autophagy has been recognized as evolutionary conserved intracellular pathway that
ensures energy, organelle, and protein homeostasis through lysosomal degradation of …
ensures energy, organelle, and protein homeostasis through lysosomal degradation of …
Repurposing antidepressants for anticancer drug discovery
Highlights•Antidepressants can be potentially repurposed for anticancer drug discovery.•
Antidepressants exhibit the antitumor activity with different mechanisms.•Repurposing …
Antidepressants exhibit the antitumor activity with different mechanisms.•Repurposing …
[HTML][HTML] Drug repurposing in non-small cell lung carcinoma: old solutions for new problems
Lung cancer is the second most common cancer and the leading cause of cancer-related
deaths in 2022. The majority (80%) of lung cancer cases belong to the non-small cell lung …
deaths in 2022. The majority (80%) of lung cancer cases belong to the non-small cell lung …
[HTML][HTML] Antidepressant drug sertraline against human cancer cells
The use of FDA-approved drugs for new indications represents a faster and more
economical way to find novel therapeutic agents for cancer therapy, compared to the …
economical way to find novel therapeutic agents for cancer therapy, compared to the …
[HTML][HTML] Drug repositioning: Using psychotropic drugs for the treatment of glioma
F You, C Zhang, X Liu, D Ji, T Zhang, R Yu, S Gao - Cancer Letters, 2022 - Elsevier
Psychotropic drugs can penetrate the blood–brain barrier and regulate the levels of
neurotransmitters and neuromodulators such as γ-aminobutyric acid, glutamate, serotonin …
neurotransmitters and neuromodulators such as γ-aminobutyric acid, glutamate, serotonin …
[HTML][HTML] A systems pharmacology approach uncovers wogonoside as an angiogenesis inhibitor of triple-negative breast cancer by targeting hedgehog signaling
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease that
lacks clinically actionable genetic alterations that limit targeted therapies. Here we explore a …
lacks clinically actionable genetic alterations that limit targeted therapies. Here we explore a …