Abstract Worldwide, antibiotic usage exceeds 100,000 tons per year and there is increasing
concern over the fate of these substances. Antibiotics are ubiquitous in the environment and …

Objective To raise awareness of the role of environmental biofilm in the emergence and
spread of antibiotic resistance and its consideration in antimicrobial stewardship …

Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic
homeostasis are significant consequences of treatment. Here, we describe three postulates …

The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an
imminent global public health problem. Local application of antibiotics might be a solution. In …

Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Quinolone antibiotics represent one of the most important classes of anti-infective agents
and, although still clinically valuable, their use has been compromised by the increasing …

Insufficient development of new antibiotics and the rising resistance of bacteria to those that
we have are putting the world at risk of losing the most widely curative class of medicines …

Antibiotics are chemotherapeutic agents, which have been a very powerful tool in the clinical
management of bacterial diseases since the 1940s. However, benefits offered by these …

The human gut contains trillions of microorganisms that influence our health by metabolizing
xenobiotics, including host-targeted drugs and antibiotics. Recent efforts have characterized …