Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
Senescence and cancer—role and therapeutic opportunities
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
[HTML][HTML] Selective autophagy regulates cell cycle in cancer therapy
K Zheng, Z He, K Kitazato, Y Wang - Theranostics, 2019 - ncbi.nlm.nih.gov
Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …
[HTML][HTML] Inhalation toxicology of vaping products and implications for pulmonary health
H Traboulsi, M Cherian, M Abou Rjeili… - International journal of …, 2020 - mdpi.com
E-cigarettes have a liquid that may contain flavors, solvents, and nicotine. Heating this liquid
generates an aerosol that is inhaled into the lungs in a process commonly referred to as …
generates an aerosol that is inhaled into the lungs in a process commonly referred to as …
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling
W Zheng, W Xie, D Yin, R Luo, M Liu, F Guo - Cell Communication and …, 2019 - Springer
Background Autophagy and ER stress are involved in maintaining some well-orchestrated
mechanisms aimed at either restoring cellular homeostasis or performing cell death …
mechanisms aimed at either restoring cellular homeostasis or performing cell death …
SAMP8 mice as a model of age-related cognition decline with underlying mechanisms in Alzheimer's disease
B Liu, J Liu, JS Shi - Journal of Alzheimer's Disease, 2020 - content.iospress.com
Alzheimer's disease (AD) is a highly age-related cognitive decline frequently attacking the
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …
Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer
X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …
Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts
Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …
Type I interferon–related kidney disorders
L Lodi, MV Mastrolia, F Bello, GM Rossi, ML Angelotti… - Kidney international, 2022 - Elsevier
Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly
affecting the biology and function of several renal cell types including podocytes, mesangial …
affecting the biology and function of several renal cell types including podocytes, mesangial …
Autophagy and cancer dormancy
Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …