Autophagy and autophagy-related pathways in cancer

J Debnath, N Gammoh, KM Ryan - Nature reviews Molecular cell …, 2023 - nature.com
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Senescence and cancer—role and therapeutic opportunities

CA Schmitt, B Wang, M Demaria - Nature reviews Clinical oncology, 2022 - nature.com
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

[HTML][HTML] Selective autophagy regulates cell cycle in cancer therapy

K Zheng, Z He, K Kitazato, Y Wang - Theranostics, 2019 - ncbi.nlm.nih.gov
Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …

[HTML][HTML] Inhalation toxicology of vaping products and implications for pulmonary health

H Traboulsi, M Cherian, M Abou Rjeili… - International journal of …, 2020 - mdpi.com
E-cigarettes have a liquid that may contain flavors, solvents, and nicotine. Heating this liquid
generates an aerosol that is inhaled into the lungs in a process commonly referred to as …

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling

W Zheng, W Xie, D Yin, R Luo, M Liu, F Guo - Cell Communication and …, 2019 - Springer
Background Autophagy and ER stress are involved in maintaining some well-orchestrated
mechanisms aimed at either restoring cellular homeostasis or performing cell death …

SAMP8 mice as a model of age-related cognition decline with underlying mechanisms in Alzheimer's disease

B Liu, J Liu, JS Shi - Journal of Alzheimer's Disease, 2020 - content.iospress.com
Alzheimer's disease (AD) is a highly age-related cognitive decline frequently attacking the
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …

Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts

S Lee, H Kim, BS Kim, S Chae, S Jung, JS Lee… - Nature …, 2024 - nature.com
Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …

Type I interferon–related kidney disorders

L Lodi, MV Mastrolia, F Bello, GM Rossi, ML Angelotti… - Kidney international, 2022 - Elsevier
Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly
affecting the biology and function of several renal cell types including podocytes, mesangial …

Autophagy and cancer dormancy

Y Akkoc, N Peker, A Akcay, D Gozuacik - Frontiers in oncology, 2021 - frontiersin.org
Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …