Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

The Calcium-Sensing Receptor (CaSR) is a member of the class C of G-proteins coupled
receptors (GPCRs), it plays a pivotal role in calcium homeostasis by directly controlling …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Fibrillar aggregates and soluble oligomers of both Amyloid-β peptides (Aβs) and
hyperphosphorylated Tau proteins (p-Tau-es), as well as a chronic neuroinflammation are …

Increasingly prevalent acute and chronic human brain diseases are scourges for the elderly.
Besides the lack of therapies, these ailments share a neuroinflammation that is …

The calcium sensing receptor (CaSR) was first identified in parathyroid glands, and its
primary role in controlling systemic calcium homeostasis by the regulation of parathyroid …

The enormous, 2–3-million-year evolutionary expansion of hominin neocortices to the
current enormity enabled humans to take over the planet. However, there appears to have …

The increase in cytosolic Ca 2+ concentration ([Ca 2+] cyt) and upregulation of calcium-
sensing receptor (CaSR) and stromal interaction molecule 2 (STIM2) along with inhibition of …

Alzheimer's disease (AD), particularly its sporadic or late-onset form (SAD/LOAD), is the
most prevalent (96–98% of cases) neurodegenerative dementia in aged people. AD's …