Formalin fixation and paraffin embedding (FFPE) is the most commonly used method
worldwide for tissue storage. This method preserves the tissue integrity but causes extensive …

Homeobox genes (HOX) are a large family of transcription factors that direct the formation of
many body structures during early embryonic development. There are 39 genes in the …

Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …

Background Hypoxia is associated with a poor prognosis in prostate cancer. This work
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …

Background Many men develop a rising PSA after initial therapy for prostate cancer. While
some of these men will develop a local or metastatic recurrence that warrants further …

Purpose Prostate-specific antigen screening has led to enormous overtreatment of prostate
cancer because of the inability to distinguish potentially lethal disease at diagnosis. We …

OBJECTIVE. The purpose of the study was to retrospectively review the frequency, sites, and
patterns of atypical metastases from prostate cancer and to determine whether any …

Localized prostate cancer (CaP) can be cured using several strategies. However, the need
to identify active substances in advanced tumor stages is tremendous, as the outcome in …

Background Clinical grading systems using clinical features alongside nomograms lack
precision in guiding treatment decisions in prostate cancer (PCa). There is a critical need for …

Background There is no cure for castration-recurrent prostate cancer (CRPC) and the
mechanisms underlying this stage of the disease are unknown. Methods We analyzed the …