Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

LR Zhu, SS Li, WQ Zheng, WJ Ni, M Cai… - Frontiers in …, 2023 - frontiersin.org
The gut microbiota not only constitutes intestinal microenvironment homeostasis and human
health but also exerts indispensable roles in the occurrence and progression of multiple liver …

[HTML][HTML] Research progress on rodent models and its mechanisms of liver injury

J Mao, L Tan, C Tian, W Wang, H Zhang, Z Zhu, Y Li - Life Sciences, 2023 - Elsevier
The liver is the most important organ for biological transformation in the body and is crucial
for maintaining the body's vital activities. Liver injury is a serious pathological condition that …

Porphyromonas gingivalis exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice

Y Gao, P Zhang, Y Wei, C Ye, D Mao… - Journal of Clinical …, 2023 - Wiley Online Library
Aim Porphyromonas gingivalis (P. gingivalis), a major periodontal pathogen, increases the
risk of systemic diseases. P. gingivalis infection is closely associated with alcoholic liver …

Curcumol suppresses CCF-mediated hepatocyte senescence through blocking LC3B–lamin B1 interaction in alcoholic fatty liver disease

X Qi, S Zheng, M Ma, N Lian, H Wang… - Frontiers in …, 2022 - frontiersin.org
Recent studies indicated that hepatocyte senescence plays an important role in the
development of alcoholic fatty liver disease (AFLD), suggesting that inhibition of hepatocyte …

Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice

H Fan, T Tu, X Zhang, Q Yang, G Liu, T Zhang… - Food and Chemical …, 2022 - Elsevier
Acute liver injury (ALI) is a common pathology of liver diseases caused by different kinds of
pathogenic factors including viral infection, alcohol intake, drugs, and chemical poisons …

Hawk tea flavonoids as natural hepatoprotective agents alleviate acute liver damage by reshaping the intestinal microbiota and modulating the Nrf2 and NF-κB …

T Xu, S Hu, Y Liu, K Sun, L Luo, L Zeng - Nutrients, 2022 - mdpi.com
Hawk tea (Litsea coreana Levl. var. lanuginosa) is a traditional herbal tea in southwestern
China, and was found to possess hepatoprotective effects in our previous study. However, it …

Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats

C Fang, J Zhang, J Han, Y Lei, Z Cao, J Pan… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Tiaogan Jiejiu Tongluo Formula (TJTF), a
traditional Chinese medicine formula, is modified from the well-known ancient prescription …

Akkermansia muciniphila Ameliorates Alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis

C Fang, J Cheng, W Jia, Y Xu - Metabolites, 2023 - mdpi.com
Alcoholic liver disease (ALD) represents a significant global health concern, yet the
available treatment options remain limited. Numerous studies have shown that gut …

1-O-Actylbritannilactone Ameliorates Alcohol-Induced Hepatotoxicity through Regulation of ROS/Akt/NF-κB-Mediated Apoptosis and Inflammation

L Xie, Z Yang, Y Wang, J Hu, Y Lu, H Zhang, S Jiang… - ACS …, 2022 - ACS Publications
1-O-Acetylbritannilactone (ABL) is a marker component of Inula britannica L. and is reported
to exhibit multiple pharmacological activities, including antiaging, anti-inflammatory, and …

Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019

M Nakano, H Yatsuhashi, S Bekki, Y Takami… - Scientific reports, 2022 - nature.com
We examined the epidemiological trends, including the distribution of sex, age, and disease
etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) …