Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy
MJ Ramaiah, AD Tangutur, RR Manyam - Life sciences, 2021 - Elsevier
The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
[HTML][HTML] An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
Means, mechanisms and consequences of adenine methylation in DNA
K Boulias, EL Greer - Nature Reviews Genetics, 2022 - nature.com
Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …
Folic acid and the prevention of birth defects: 30 years of opportunity and controversies
KS Crider, YP Qi, LF Yeung, CT Mai… - Annual review of …, 2022 - annualreviews.org
For three decades, the US Public Health Service has recommended that all persons capable
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects …
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects …
The role of snail in EMT and tumorigenesis
Y Wang, J Shi, K Chai, X Ying… - Current cancer drug …, 2013 - ingentaconnect.com
Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized,
immobile epithelial cells lose tight junctions, associated adherence, and become migratory …
immobile epithelial cells lose tight junctions, associated adherence, and become migratory …
Histone methylation: a dynamic mark in health, disease and inheritance
EL Greer, Y Shi - Nature Reviews Genetics, 2012 - nature.com
Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
Neurobiology of resilience: interface between mind and body
Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …
Non-histone protein methylation as a regulator of cellular signalling and function
Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …
prevalent post-translational modification and as an important regulator of cellular signal …
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
K Hasegawa, S Wakino, P Simic, Y Sakamaki… - Nature medicine, 2013 - nature.com
Abstract Sirtuin 1 (Sirt1), a NAD+-regulated deacetylase with numerous known positive
effects on cellular and whole-body metabolism, is expressed in the renal cortex and …
effects on cellular and whole-body metabolism, is expressed in the renal cortex and …
Chromosome territories
Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …
statement, the possible contribution of nuclear architecture studies to the field of …