Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy

MJ Ramaiah, AD Tangutur, RR Manyam - Life sciences, 2021 - Elsevier
The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

[HTML][HTML] An epigenetic role of mitochondria in cancer

Y Liu, C Chen, X Wang, Y Sun, J Zhang, J Chen, Y Shi - Cells, 2022 - mdpi.com
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Means, mechanisms and consequences of adenine methylation in DNA

K Boulias, EL Greer - Nature Reviews Genetics, 2022 - nature.com
Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Folic acid and the prevention of birth defects: 30 years of opportunity and controversies

KS Crider, YP Qi, LF Yeung, CT Mai… - Annual review of …, 2022 - annualreviews.org
For three decades, the US Public Health Service has recommended that all persons capable
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects …

The role of snail in EMT and tumorigenesis

Y Wang, J Shi, K Chai, X Ying… - Current cancer drug …, 2013 - ingentaconnect.com
Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized,
immobile epithelial cells lose tight junctions, associated adherence, and become migratory …

Histone methylation: a dynamic mark in health, disease and inheritance

EL Greer, Y Shi - Nature Reviews Genetics, 2012 - nature.com
Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Neurobiology of resilience: interface between mind and body

F Cathomas, JW Murrough, EJ Nestler, MH Han… - Biological …, 2019 - Elsevier
Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …

Non-histone protein methylation as a regulator of cellular signalling and function

KK Biggar, SSC Li - Nature reviews Molecular cell biology, 2015 - nature.com
Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

K Hasegawa, S Wakino, P Simic, Y Sakamaki… - Nature medicine, 2013 - nature.com
Abstract Sirtuin 1 (Sirt1), a NAD+-regulated deacetylase with numerous known positive
effects on cellular and whole-body metabolism, is expressed in the renal cortex and …

Chromosome territories

T Cremer, M Cremer - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …