Recent Report on Indoles as a Privileged anti-viral Scaffold in Drug Discovery

A Singh, C Bhutani, P Khanna, S Talwar… - European Journal of …, 2024 - Elsevier
In recent years, viral infections such as COVID-19, Zika virus, Nipah virus, Ebola, Influenza,
Monkeypox, and Dengue have substantially impacted global health. These outbreaks have …

Design, synthesis, antibacterial and antiviral evaluation of chalcone derivatives containing benzoxazole

N Zhang, W Zeng, Q Zhou, Z Sun, K Meng, Y Qin… - Arabian Journal of …, 2024 - Elsevier
In this study, 24 chalcone derivatives containing benzoxazole were designed and
synthesized, and the structures of all target compounds were confirmed by NMR and HRMS …

Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety

B He, Y Hu, Y Qin, Y Zhang, X Luo, Z Wang, W Xue - Molecular Diversity, 2024 - Springer
A series of indole derivatives containing quinoline structures were designed and
synthesized. The synthesized compounds were characterized by NMR and HRMS. And W14 …

Design, synthesis, and bioactivity studies of chalcone derivatives containing [1, 2, 4]-triazole-[4, 3-a]-pyridine

N Zhang, W Zeng, Z Sun, Q Zhou, K Meng, Y Hu, Y Qin… - Fitoterapia, 2024 - Elsevier
In this study, 30 chalcone derivatives containing [1, 2, 4]-triazole-[4, 3-a]-pyridine were
designed and synthesized. The results of antibacterial activity showed that EC 50 values of …

Myricetin derivatives containing the benzoxazinone moiety discovered as potential anti-tobacco mosaic virus agents

C Yuan, J Tian, Q Zhou, H Xin, Y Liu, T Deng, W Zeng… - Fitoterapia, 2024 - Elsevier
A series of myricetin derivatives containing benzoxazinone were designed and synthesized.
The structures of all compounds were characterized by NMR and HRMS. The structure of Y4 …

[HTML][HTML] Design and research of new virulence factor inhibitors for plant bacterial disease control

W Zeng, Z Sun, Y Liu, Q Zhou, Y Zhang, Y Qiu… - Arabian Journal of …, 2024 - Elsevier
In this work, various chalcone derivatives incorporating piperazine-isopropanolamine were
elaborately designed and synthesized. The antibacterial efficacy revealed that compound Z6 …

Synthesis and biological studies of acetophenone-based novel chalcone, semicarbazone, thiosemicarbazone and indolone derivatives: Structure-Activity relationship …

A Farzaliyeva, H Şenol, P Taslimi, F Çakır… - Journal of Molecular …, 2025 - Elsevier
This study presents the synthesis and evaluation of nine acetophenone derivatives (1–9),
with compounds 2, 4, 5, 6, 7, and 9 being novel and synthesized for the first time. These …

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

WH Wang, ZR Li, DX Zhu, JY Chen… - Pest Management …, 2024 - Wiley Online Library
BACKGROUND Xanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most
destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant …

[HTML][HTML] Chalcone derivatives containing thiazole fragment: Synthesis and antifungal activity

T Zhang, C Yuan, Q Zhou, H Xin, Y Liu, J Tian… - Journal of Saudi …, 2023 - Elsevier
Abstract 28 chalcone derivatives containing thiazole fragment were synthesized. The results
of antifungal bioactivity tests suggested that most of the compounds possessed superior in …

Synthesis and Antifungal Activity of Chalcone Derivatives Containing 1, 3, 4‐Thiadiazole

T Zhang, Y Liu, H Xin, J Tian, T Deng… - Chemistry & …, 2024 - Wiley Online Library
Abstract 24 chalcone derivatives containing 1, 3, 4‐thiadiazole were synthesized. The
results of bioactivity tests indicated that some of the target compounds exhibited superior …