Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases

NS Mohd Sairazi… - … Based Complementary and …, 2020 - Wiley Online Library
In recent years, natural products, which originate from plants, animals, and fungi, together
with their bioactive compounds have been intensively explored and studied for their …

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications

H Xu, E Wang, F Chen, J Xiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

Neuroprotective effect of curcumin against cerebral ischemia-reperfusion via mediating autophagy and inflammation

L Huang, C Chen, X Zhang, X Li, Z Chen… - Journal of Molecular …, 2018 - Springer
Curcumin, a polyphenolic compound extracted from Curcuma longa, has drawn attention for
its effective bioactivities against ischemia-induced injury. This study aimed to evaluate the …

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

N Qin, X Lu, Y Liu, Y Qiao, W Qu, F Feng… - European Journal of …, 2021 - Elsevier
Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …

[HTML][HTML] Low back pain and osteoarthritis pain: a perspective of estrogen

H Pang, S Chen, DM Klyne, D Harrich, W Ding… - Bone Research, 2023 - nature.com
Low back pain (LBP) is the world's leading cause of disability and is increasing in
prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) …

[HTML][HTML] Electroacupuncture Inhibits Neuronal Autophagy and Apoptosis via the PI3K/AKT Pathway Following Ischemic Stroke

MM Wang, M Zhang, YS Feng, Y Xing… - Frontiers in cellular …, 2020 - frontiersin.org
Electroacupuncture (EA) is a safe and effective therapy for ischemic stroke in both clinical
and laboratory settings. However, the underlying mechanism behind EA treatment for stroke …

Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21–5p and miR-331–5p

HS Zhang, MF Liu, XY Ji, CR Jiang, ZL Li, B OuYang - Life sciences, 2019 - Elsevier
Background The protective effects of gastrodin and rhynchophylline in ischaemic injury have
been reported. However, the underlying mechanism and the effect of the combination of …

Uncaria rhynchophylla and its major constituents on central nervous system: a review on their pharmacological actions

W Yang, SP Ip, L Liu, YF Xian… - Current vascular …, 2020 - ingentaconnect.com
Background: Uncaria rhynchophylla (Miq.) Jacks (Rubinaceae), a common herbal medicine
known as Gou-teng in Chinese, is commonly used in Chinese medicine practice for the …

[HTML][HTML] MicroRNA-107 inhibits tumor growth and metastasis by targeting the BDNF-mediated PI3K/AKT pathway in human non-small lung cancer Retraction in …

H Xia, Y Li, X Lv - International journal of oncology, 2016 - spandidos-publications.com
Abnormal expression of microRNA-107 (miR-107) was found in non-small cell lung cancer
(NSCLC). However, little is known about its role and molecular mechanism in NSCLC …