The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Human pluripotent stem cells (hPSCs) represent a renewable source of pancreatic beta
cells for both basic research and therapeutic applications. Given this outstanding potential …

Human pluripotent stem cells represent a potentially unlimited source of functional
pancreatic endocrine lineage cells. Here we report a highly efficient approach to induce …

In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion
and subsequent differentiation into insulin-producing beta cells would be extremely …

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell
therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Multiple growth-and differentiation-inducing polypeptide factors bind to and activate
transmembrane receptors tyrosine kinases (RTKs), to instigate a plethora of biochemical …

Apoptotic cell death in pancreatic β-cells is involved in the pathogenesis of diabetes. Signals
from death receptors and DNA damage have been widely accepted as being triggers of …

Most insulin-producing β-cells in the fetal mouse pancreas arise during the secondary
transition, a wave of differentiation starting at embryonic day 13. Here, we show that …