The role of oncomirs in the pathogenesis and treatment of breast cancer

M Hemmatzadeh, H Mohammadi… - Biomedicine & …, 2016 - Elsevier
Breast cancer, the most common cancer among women, is a heterogeneous and complex
disease, which detail of its precise progression mechanisms is less understood. So, an …

Roles of versican in cancer biology-tumorigenesis, progression and metastasis

WW Du, W Yang, AJ Yee - 2013 - digitum.um.es
Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a
key role in both malignant transformation and tumor progression. Increased versican …

Verbascoside promotes apoptosis by regulating HIPK2–p53 signaling in human colorectal cancer

L Zhou, Y Feng, Y Jin, X Liu, H Sui, N Chai, X Chen… - BMC cancer, 2014 - Springer
Background We investigated the role of the HIPK2–p53 signaling pathway in tumorigenesis
and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and …

Proteoglycans in the pathogenesis of hormone-dependent cancers: mediators and effectors

G Tzanakakis, EM Giatagana, A Kuskov, A Berdiaki… - Cancers, 2020 - mdpi.com
Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in
therapy, the treatment of hormone-dependent cancers remains an unmet health need. The …

Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer

K Kyriakopoulou, E Kefali, Z Piperigkou, H Bassiony… - Cellular …, 2018 - Elsevier
Breast cancer is the most common malignancy among women worldwide. The role of
epidermal growth factor receptor (EGFR) in many epithelial malignancies has been …

The role of versican in modulating breast cancer cell self-renewal

WW Du, L Fang, X Yang, W Sheng, BL Yang… - Molecular cancer …, 2013 - AACR
Versican is highly expressed during the early stages of tissue development and its
expression is elevated during wound repair and tumor growth. There is little literature on the …

Targeting of stromal versican by miR-144/199 inhibits multiple myeloma by downregulating FAK/STAT3 signalling

N Gupta, R Kumar, T Seth, B Garg, A Sharma - RNA biology, 2020 - Taylor & Francis
The abnormal growth of malignant plasma cells in Multiple Myeloma (MM) requires bone
marrow (BM) niche consisting of proteoglycans, cytokines, etc. Versican (VCAN), a …

Genome-Wide Association Study and FST Analysis Reveal Four Quantitative Trait Loci and Six Candidate Genes for Meat Color in Pigs

H Liu, L Hou, W Zhou, B Wang, P Han, C Gao… - Frontiers in …, 2022 - frontiersin.org
Meat color is the primary criterion by which consumers evaluate meat quality. However,
there are a few candidate genes and molecular markers of meat color that were reported for …

The role of versican G3 domain in regulating breast cancer cell motility including effects on osteoblast cell growth and differentiation in vitro– evaluation towards …

WW Du, L Fang, W Yang, W Sheng, Y Zhang, A Seth… - BMC cancer, 2012 - Springer
Background Versican is detected in the interstitial tissues at the invasive margins of breast
carcinoma, is predictive of relapse, and negatively impacts overall survival rates. The …

Whole genome sequencing analysis to identify candidate genes associated with the rib eye muscle area in Hu sheep

Y Zhao, X Zhang, F Li, D Zhang, Y Zhang, X Li… - Frontiers in …, 2022 - frontiersin.org
In sheep meat production, the rib eye area is an important index to evaluate carcass traits.
However, conventional breeding programs have led to slow genetic progression in rib eye …