[HTML][HTML] Recent progress and challenges in the development of antisense therapies for myotonic dystrophy type 1

T De Serres-Bérard, S Ait Benichou, D Jauvin… - International journal of …, 2022 - mdpi.com
Myotonic dystrophy type 1 (DM1) is a dominant genetic disease in which the expansion of
long CTG trinucleotides in the 3′ UTR of the myotonic dystrophy protein kinase (DMPK) …

[HTML][HTML] Comprehensive Cardiovascular Management of Myotonic Dystrophy Type 1 Patients: A Report from the Italian Neuro-Cardiology Network

V Russo, G Antonini, R Massa, C Casali… - Journal of …, 2024 - mdpi.com
Myotonic dystrophy is a hereditary disorder with systemic involvement. The Italian Neuro-
Cardiology Network-“Rete delle Neurocardiologie”(INCN-RNC) is a unique collaborative …

Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy

KY Lee, C Seah, C Li, YF Chen, CY Chen… - Human Molecular …, 2022 - academic.oup.com
Myotonic dystrophy (DM) is caused by expansions of C (C) TG repeats in the non-coding
regions of the DMPK and CNBP genes, and DM patients often suffer from sudden cardiac …

[HTML][HTML] Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels

M Pierre, M Djemai, CA Chapotte-Baldacci… - Frontiers in …, 2023 - frontiersin.org
Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and
myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and …

[HTML][HTML] Electrophysiological basis of cardiac arrhythmia in a mouse model of myotonic dystrophy type 1

VKM Ginjupalli, M Cupelli, JB Reisqs… - Frontiers in …, 2023 - frontiersin.org
Introduction: Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by
the increased number of CTG repeats in 3′ UTR of Dystrophia Myotonia Protein Kinase …

[HTML][HTML] Myotonic Dystrophy: From Molecular Pathogenesis to Therapeutics

L Timchenko - International Journal of Molecular Sciences, 2022 - mdpi.com
Current studies concerning myotonic dystrophy type 1 (DM1) are in the process of
transitioning from molecular investigations to preclinical and clinical trials. Several papers …

[HTML][HTML] Prevalence of Steinert's Myotonic Dystrophy and Utilization of Healthcare Services: A Population-Based Cross-Sectional Study

L Hernáez, AC Zoni, MF Domínguez-Berjón… - Healthcare, 2024 - mdpi.com
Myotonic dystrophy type I (MDI) is the most common muscular dystrophy in adults. The main
objectives of this study were to determine the prevalence of MDI in the Community of Madrid …

[HTML][HTML] Natural history of cardiac involvement in myotonic dystrophy type 1–Emphasis on the need for lifelong follow-up

H Petri, BJY Mohammad, AT Kristensen… - International Journal of …, 2024 - Elsevier
Background Cardiac involvement represents a major cause of morbidity and mortality in
patients with myotonic dystrophy type 1 (DM1) and prevention of sudden cardiac death …

[HTML][HTML] Case report: A rare complication after the implantation of a cardiac implantable electronic device: Contralateral pneumothorax with pneumopericardium and …

SW Lo, JY Chen - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Cardiac implantable electronic devices (CIED) including pacemakers (PM), implantable
cardioverter defibrillators (ICD), and cardiac resynchronized therapy (CRT) have become …

[HTML][HTML] Evaluation of index of cardiac electrophysiological balance in patients with myotonic dystrophy type 1

M Okşul, Ö Bilge, A Türken, F Işık, A Akyüz, M Çap… - Cureus, 2023 - ncbi.nlm.nih.gov
Background: Myotonic dystrophy type 1 (MD1), which is characterized by decreased muscle
tone, progressive muscle weakness, and cardiac involvement, is an autosomal dominant …