[HTML][HTML] Targeting TRPV1 for Cancer Pain Relief: Can It Work?
A Szallasi - Cancers, 2024 - mdpi.com
Simple Summary Medical control of cancer pain is often unsatisfactory. Narcotic drugs
(opioids) are effective pain killers, but they have important negative effects on the central …
(opioids) are effective pain killers, but they have important negative effects on the central …
[HTML][HTML] Current insights and therapeutic strategies for targeting TRPV1 in neuropathic pain management
Neuropathic pain, a common symptom of several disorders, exerts a substantial
socioeconomic burden worldwide. Transient receptor potential vanilloid 1 (TRPV1), a non …
socioeconomic burden worldwide. Transient receptor potential vanilloid 1 (TRPV1), a non …
TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates
K Socała, M Jakubiec, M Abram, J Mlost… - Progress in …, 2024 - Elsevier
Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1),
also known as capsaicin receptor, in 1997 was a milestone achievement in the research on …
also known as capsaicin receptor, in 1997 was a milestone achievement in the research on …
Promising therapeutic targets for the treatment of urine storage dysfunction: what's the status?
KE Andersson - Expert Opinion on Therapeutic Targets, 2024 - Taylor & Francis
Introduction Opinions differ on what drugs have both a rationale and a development
potential for the treatment of bladder storage dysfunction. Areas covered In the present …
potential for the treatment of bladder storage dysfunction. Areas covered In the present …
[HTML][HTML] The Endocannabinoid Peptide RVD-Hemopressin Is a TRPV1 Channel Blocker
C Suárez-Suárez, S González-Pérez… - Biomolecules, 2024 - mdpi.com
Neurotransmission is critical for brain function, allowing neurons to communicate through
neurotransmitters and neuropeptides. RVD-hemopressin (RVD-Hp), a novel peptide …
neurotransmitters and neuropeptides. RVD-hemopressin (RVD-Hp), a novel peptide …
Association between Variants of the TRPV1 Gene and Body Composition in Sub-Saharan Africans
M Giannì, M Antinucci, S Bertoncini, L Taglioli… - Genes, 2024 - mdpi.com
In humans, the transient receptor potential vanilloid 1 (TRPV1) gene is activated by
exogenous (eg, high temperatures, irritating compounds such as capsaicin) and …
exogenous (eg, high temperatures, irritating compounds such as capsaicin) and …
Discovery of N-(1, 4-Benzoxazin-3-one) urea analogs as Mode-Selective TRPV1 antagonists
G Huang, A Jung, LX Li, N Do, S Jung, Y Jeon… - Bioorganic & Medicinal …, 2024 - Elsevier
Abstract A series of 1, 4-benzoxazin-3-one analogs were investigated to discover mode-
selective TRPV1 antagonists, since such antagonists are predicted to minimize target-based …
selective TRPV1 antagonists, since such antagonists are predicted to minimize target-based …
[HTML][HTML] History of TRP channels and lower urinary tract function and dysfunction
KE Andersson - Continence, 2024 - Elsevier
The history of TRP channels and bladder started in the 1980-ies with the studies of Maggi
and collaborators, who created the basis for using capsaicin and other vanilloids in LUT …
and collaborators, who created the basis for using capsaicin and other vanilloids in LUT …
[HTML][HTML] Research trends and frontier hotspots of TRPV1 based on bibliometric and visualization analyses
J Zeng, Y Lu, H Chu, L Lu, Y Chen, K Ji, Y Lin, J Li… - Heliyon, 2024 - cell.com
Background Transient receptor potential vanilloid type1 (TRPV1) is a non-selective cation
channel with multiple activation mechanisms, which has received increasing attention since …
channel with multiple activation mechanisms, which has received increasing attention since …