Forkhead box O (Foxo) transcription factors are emerging as critical transcriptional
integrators among pathways regulating differentiation, proliferation, and survival, yet the role …

Chronic kidney disease (CKD) is now clearly recognized as a public health problem
worldwide. Patients with CKD display a substantial increase in end-stage renal disease …

Nitric oxide (NO) produced by the endothelium is an important protective molecule in the
vasculature. It is generated by the enzyme endothelial NO synthase (eNOS). Similar to all …

Endothelial nitric oxide (NO) is generated by constitutively active endothelial nitric oxide
synthase (eNOS), an essential enzyme responsible for cardiovascular homeostasis …

In this review we consider the effects of endogenous and pharmacological levels of nitrite
under conditions of hypoxia. In humans, the nitrite anion has long been considered as …

Background—Two types of cells are cultured from the human peripheral blood, early
endothelial progenitor cells (EPCs) and outgrowth endothelial cells (OECs), as previously …

The mechanisms through which hematopoietic cytokines accelerate revascularization are
unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Background—Cell therapy with bone marrow–derived stem/progenitor cells is a novel option
for improving neovascularization and cardiac function in ischemic heart disease. Circulating …

Accumulating evidence indicates the impact of endothelial progenitor cells (EPCs) in
vascular repair. In patients, the number of EPCs is negatively correlated with the severity of …